Radiation from Medical Procedures in the Pathogenesis of Cancer and Ischemic Heart Disease: Dose-Response Studies with Physicians per 100,000 Population John W. Gofman, M.D., Ph. D. Professor Emeritus, Molecular and Cell Biology University of California, Berkeley Edited by Egan O'Connor * Hypothesis-1: Medical radiation is a highly important cause (probably the principal cause) of cancer mortality in the United States during the Twentieth Century. Medical radiation means, primarily, exposure by xrays (including fluoroscopy and CT scans). * Hypothesis-2: Medical radiation, received even at very low and moderate doses, is an important cause of death from Ischemic Heart Disease; the probable mechanism is radiation-induction of mutations in the coronary arteries, resulting in dysfunctional clones (mini-tumors) of smooth muscle cells. ------------------------------------------------------------------ First Edition: 1999 C.N.R. Book Division Committee for Nuclear Responsibility, Inc. Post Office Box 421993 San Francisco, California 94142 U.S.A.